6-MP (Mercaptopurine)

What Is 6-MP (Mercaptopurine) Tablet?

6-MP (Mercaptopurine) is an immunosuppressive medication commonly used in the treatment of certain types of cancers and autoimmune diseases.

It is particularly effective in treating acute lymphoblastic leukemia (ALL) and is also used for inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis.

How 6-MP (Mercaptopurine) Tablet Works?

Mercaptopurine is a purine analog, which means it interferes with DNA and RNA synthesis in rapidly dividing cells, like cancer cells or cells involved in an autoimmune response. By disrupting these processes, it helps to slow or stop the growth of abnormal cells.

Uses Of 6-MP Tablet

▶ Acute Lymphoblastic Leukemia (ALL): Often used as part of a combination chemotherapy regimen.

▶ Chronic Myeloid Leukemia (CML): Occasionally used in chronic management.

▶ Inflammatory Bowel Disease (IBD): Used as an immunosuppressant to maintain remission in Crohn's disease and ulcerative colitis.

Dosage

The dosage of 6-MP is individualized based on the condition being treated, the patient’s weight, and the response to therapy. It’s usually taken orally once daily.

Side Effects

➦ Common Side Effects:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Fatigue

➦ Serious Side Effects:

• Bone marrow suppression (leading to anemia, leukopenia, thrombocytopenia)
• Liver toxicity (elevated liver enzymes, jaundice)
• Increased risk of infections due to immunosuppression
• Increased risk of secondary malignancies (rare but possible with long-term use)

Precautions

• Drug Interactions:

Mercaptopurine can interact with other medications, such as allopurinol (used for gout), which can increase the risk of toxicity. Careful adjustment of dosage may be needed.

• Thiopurine Methyltransferase (TPMT) Deficiency:

Patients with a genetic deficiency of the enzyme TPMT may be at increased risk of severe bone marrow suppression. Genetic testing can be done to assess this risk before starting treatment.

• Pregnancy and Breastfeeding:

6-MP is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.